Dwyer, J. H., Navab, M., Dwyer, K. M., Hassan, K., Sun, P., Shircore, A., Hama-Levy, S., Hough, G., Wang, X., Drake, T., Merz, C. N., and Fogelman, A. M. Oxygenated carotenoid lutein and progression of early atherosclerosis: the Los Angeles atherosclerosis study. Dietary lutein plus zeaxanthin and choline intake is interactively associated with cognitive flexibility in middle-adulthood in adults with overweight and obesity. Richer, S. ARMD--pilot (case series) environmental intervention data. Clinical trial of lutein in patients with retinitis pigmentosa receiving vitamin A. Arch.Ophthalmol. Arch Ophthalmol 1995;113:518-23. Br.J Nutr 1999;82(3):203-212. Select a condition to view a list of vitamins. 2002;76(3):595-603. View abstract. 2002;75(3):540-549. Arch Neurol 2000;57:956-63. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Central retinal thickness is positively correlated with macular pigment optical density. Retina 2008;28(1):103-110. 1996;126(9):2098-2106. View abstract. J Nutr 1997;127:1636S-45S. Another convincing factor is that after the researchers tested effects of the carotenoid on human arteries that wereremoved during surgery, fewer white cells were present within the arteries after lutein supplementation compared to controls, suggesting that less inflammation and clogging occurred. View abstract. This includes a 2018 study in which researchers concluded: Dietary lutein supplementation may be a promising alternative and/or adjunct therapeutic candidate against breast cancer.. Invest Ophthalmol.Vis.Sci. Sedating antihistamines are also called first-generation antihistamines because they were the first View abstract. Kotagiri SR, Morde A, Rai D, et al. Clin Sci (Lond) 2002;102:447-56. 2012;53(10):6178-6186. 2008;87(6):1837-1843. View abstract. Bone, R. A., Landrum, J. T., Mayne, S. T., Gomez, C. M., Tibor, S. E., and Twaroska, E. E. Macular pigment in donor eyes with and without AMD: a case-control study. View abstract. View abstract. Kawabata, F. and Tsuji, T. Effects of dietary supplementation with a combination of fish oil, bilberry extract, and lutein on subjective symptoms of asthenopia in humans. Invest Ophthalmol.Vis.Sci. 2009;102(2):186-190. Long-term nutrient intake and early age-related nuclear lens opacities. 2011;52(11):8174-8178. View abstract. Can.J.Ophthalmol. Arch Ophthalmol 1993;111:104-9.. View abstract. Bartlett, H. E. and Eperjesi, F. A randomised controlled trial investigating the effect of lutein and antioxidant dietary supplementation on visual function in healthy eyes. Br.J.Nutr. B. Lutein and zeaxanthin concentrations in plasma after dietary supplementation with egg yolk. Information from this source is evidence-based and objective, and without commercial influence. Lutein is an antioxidant often used in the treatment or prevention of eye diseases. Sommerburg, O. G., Siems, W. G., Hurst, J. S., Lewis, J. W., Kliger, D. S., and van Kuijk, F. J. Lutein and zeaxanthin are associated with photoreceptors in the human retina. Qiu Z, Chen X, Geng T, et al. With dry eye disease, also known as dry eye syndrome, your eyes dont make enough lubrication to coat your eyes. This can cause red, itchy, burning, eyes, temporary blurriness, and a feeling as if theres sand in your eye. According to a 2016 study, lutein may help reduce these symptoms. How much lutein do you need? A one year study of the macular pigment: the effect of 140 days of a lutein supplement. Aside from protecting eyes, lutein uses also include helping prevent skin disorders, several types of cancer including colon or breast cancer, type 2 diabetes, and risk factors associated with coronary heart disease. A., Gao, Y. T., Goodman, M. T., Hallmans, G., Helzlsouer, K. J., Hoffman-Bolton, J., Hulten, K., Sesso, H. D., Sowell, A. L., Tamimi, R. M., Toniolo, P., Wilkens, L. R., Winkvist, A., Zeleniuch-Jacquotte, A., Zheng, W., and Hankinson, S. E. Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies. View abstract. 7-15-2001;391(2):160-164. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Gartner, C., Stahl, W., and Sies, H. Preferential increase in chylomicron levels of the xanthophylls lutein and zeaxanthin compared to beta-carotene in the human. Hammond, B. R., Jr., Fletcher, L. M., and Elliott, J. G. Glare disability, photostress recovery, and chromatic contrast: relation to macular pigment and serum lutein and zeaxanthin. View abstract. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. View abstract. When taken in high doses, potential lutein side effects can includeharmless yellowing of the skin called carotenemia or vomiting, although these are rare. Nutr.J. Adackapara, C. A., Sunness, J. S., Dibernardo, C. W., Melia, B. M., and Dagnelie, G. Prevalence of cystoid macular edema and stability in oct retinal thickness in eyes with retinitis pigmentosa during a 48-week lutein trial. 2006;124(8):1151-1162. Snellen, E. L., Verbeek, A. L., Van Den Hoogen, G. W., Cruysberg, J. R., and Hoyng, C. B. Neovascular age-related macular degeneration and its relationship to antioxidant intake. WebLutein is concentrated in the primate retina, where together with zeaxanthin it forms the macular pigment. BMC Pregnancy Childbirth 2022;22(1):427. Plant foods and colon cancer: an assessment of specific foods and their related nutrients (United States). Therapeutic effect of lutein supplement on non-proliferative diabetic retinopathy: a retrospective study. Pratt S. Dietary prevention of age-related macular degeneration. Arch.Ophthalmol. Creatine therapy in myophosphorylase deficiency (McArdle disease): a placebo-controlled crossover trial. View abstract. View abstract. Eichler, O., Sies, H., and Stahl, W. Divergent optimum levels of lycopene, beta-carotene and lutein protecting against UVB irradiation in human fibroblastst. View abstract. Zhao, X., Aldini, G., Johnson, E. J., Rasmussen, H., Kraemer, K., Woolf, H., Musaeus, N., Krinsky, N. I., Russell, R. M., and Yeum, K. J. 10-10-2003;2:12. 2002;80(4):368-371. 2008;126(3):354-364. Shao, A. and Hathcock, J. N. Risk assessment for the carotenoids lutein and lycopene. Kang T, Liu Y, Chen X, et al. Ma L, Hao ZX, Liu RR, et al. Albanes D, Virtamo J, Taylor PR, et al. J Nutr 2021;151(3):615-627. Berson EL, Rosner B, Sandberg MA, et al. View abstract. Rapp, L. M., Maple, S. S., and Choi, J. H. Lutein and zeaxanthin concentrations in rod outer segment membranes from perifoveal and peripheral human retina. Just one drop of this thick cream will moisturize dry hands or itchy eczema spots. Br.J.Ophthalmol. View abstract. View abstract. What is the best eye vitamin for macular degeneration? Atherosclerosis Risk in Communities. Kostic D, White WS, Olson JA. Andersen, L. F., Jacobs, D. R., Jr., Gross, M. D., Schreiner, P. J., Dale, Williams O., and Lee, D. H. Longitudinal associations between body mass index and serum carotenoids: the CARDIA study. J.Ocul.Pharmacol.Ther. Am J Clin Nutr 2006;83(1):163-169. View abstract. J.Nutr. View abstract. View abstract. Biosci Biotechnol Biochem 2019;83(12):2372-4. View abstract. Glabska D, Guzek D, Zakrzewska P, Lech G. Intake of Lutein and Zeaxanthin as a Possible Factor Influencing Gastrointestinal Symptoms in Caucasian Individuals with Ulcerative Colitis in Remission Phase. View abstract. Wang X, Jiang C, Zhang Y, et al. 2005;15 Suppl 2:S140-S149. It contains 20 mg of lutein, 4 mg of zeaxanthin, 408mg of vitamin C, 242.3mg of vitamin E, 30mg of zinc, and 1.5mg of copper. Feng L, Nie K, Jiang H, Fan W. Effects of lutein supplementation in age-related macular degeneration. View abstract. Optometry 2004;75:216-30. Macular yellow pigment. View abstract. Am J Clin Nutr 2012;96(4):902-910. J Aging Res 2019;2019:3709402. View abstract. Garca-Layana A, Recalde S, Alamn AS, Robredo PF. View abstract. A. Nutrients 2020;12(2):274. Br.J.Nutr. Am J Clin Nutr 2004;80:1508-20. Saxena, S., Srivastava, P., and Khanna, V. K. Antioxidant supplementation improves platelet membrane fluidity in idiopathic retinal periphlebitis (Eales' disease). Eur.J.Clin.Nutr. View abstract. Traditionally lutein is characterized by its blue light filtering and anti-oxidant properties. Zhang Y, Knol LL, Tan L. Association between dietary lutein/zeaxanthin intake and metabolic syndrome among US females: An analysis of national health and examination surveys 2015-2018. Vitamin A and carotenoids and the risk of Parkinson's disease: a systematic review and meta-analysis. Schweiggert, R. M., Mezger, D., Schimpf, F., Steingass, C. B., and Carle, R. Influence of chromoplast morphology on carotenoid bioaccessibility of carrot, mango, papaya, and tomato. Rock, C. L., Flatt, S. W., Wright, F. A., Faerber, S., Newman, V., Kealey, S., and Pierce, J. P. Responsiveness of carotenoids to a high vegetable diet intervention designed to prevent breast cancer recurrence. 2009;41(9):1752-1760. Plasma kinetics of lutein, zeaxanthin, and 3-dehydro-lutein after multiple oral doses of a lutein supplement. Br J Nutr 2004;92(1):113-118. View abstract. Lutein, zeaxanthin, macular pigment, and visual function in adult cystic fibrosis patients. This carotenoid is obtained from both foods and supplements, which are generally considered safe. 2013;91(1):6-11. View abstract. View abstract. A., Klein, B. E., Klein, R., Palta, M., Bowen, P. E., and Greger, J. L. Serum carotenoids and tocopherols and incidence of age-related nuclear cataract. Of those 20,zeaxanthin and lutein are the only two that are deposited in high quantities into the macular portion of the eyes. Trumbo, P. R. and Ellwood, K. C. Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claims. Djuric, Z., Uhley, V. E., Naegeli, L., Lababidi, S., Macha, S., and Heilbrun, L. K. Plasma carotenoids, tocopherols, and antioxidant capacity in a 12-week intervention study to reduce fat and/or energy intakes. J Nutr.Biochem. Eur.J.Clin.Nutr. View abstract. Am J Clin Nutr 1999;70(4):490-494. Am.J.Clin.Nutr. Seddon JM, Ajani UA, Sperduto RD, et al. Morganti, P., Fabrizi, G., and Bruno, C. Protective effects of oral antioxidants on skin and eye function. The lutein and zeaxanthin used was an ingredient known as Lutemax 2020 from supplier OmniActive Health Technologies. Palombo, P., Fabrizi, G., Ruocco, V., Ruocco, E., Fluhr, J., Roberts, R., and Morganti, P. Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study. In addition, reduced Am.J.Clin.Nutr. View abstract. Maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age: The GUSTO Study. Eliassen, A. H., Hendrickson, S. J., Brinton, L. A., Buring, J. E., Campos, H., Dai, Q., Dorgan, J. F., Franke, A. Kaya, S., Weigert, G., Pemp, B., Sacu, S., Werkmeister, R. M., Dragostinoff, N., Garhofer, G., Schmidt-Erfurth, U., and Schmetterer, L. Comparison of macular pigment in patients with age-related macular degeneration and healthy control subjects - a study using spectral fundus reflectance. 2007;16(10):2008-2015. Neuroepidemiology. Am J Clin Nutr 2016;103(2):481-94. Castenmiller, J. J., Lauridsen, S. T., Dragsted, L. O., het Hof, K. H., Linssen, J. P., and West, C. E. beta-carotene does not change markers of enzymatic and nonenzymatic antioxidant activity in human blood. Exp Eye Res 1997;65:57-62. Mahmassani HA, Switkowski KM, Scott TM, et al. A., Kardinaal, A. F., Van, Poppel G., and Van, Norren D. Lens aging in relation to nutritional determinants and possible risk factors for age-related cataract. Ophthalmologica 2017;237(3):159-66. Mol.Nutr.Food Res. View abstract. View abstract. 2012;90(5):e399-e403. 2013;54(1):476-481. 2002;75(5):503-506. A., Snodderly, D. M., Klein, M. L., Wooten, B. R., and Chappell, R. Macular pigment density and age-related maculopathy in the Carotenoids in Age-Related Eye Disease Study. Chen J, Jiang W, Shao L, Zhong D, Wu Y, Cai J. Bates, C. J., Chen, S. J., Macdonald, A., and Holden, R. Quantitation of vitamin E and a carotenoid pigment in cataractous human lenses, and the effect of a dietary supplement. Am.J Clin.Nutr 1996;64(4):594-602. pii: E426. 2012;22(2):216-225. Upritchard, J. E., Schuurman, C. R., Wiersma, A., Tijburg, L. B., Coolen, S. A., Rijken, P. J., and Wiseman, S. A. Online ahead of print. View abstract. Am J Clin Nutr 2004;79 1045-52. View abstract. Eur.J Clin.Nutr. WebLutein is a type of vitamin that is called carotenoid. Am J Epidemiol 1999;149:801-9. View abstract. JAMA 1994;272:1413-20. View abstract. Ann Neurol. Liu XH, Yu RB, Liu R, et al. Bahrami, H., Melia, M., and Dagnelie, G. Lutein supplementation in retinitis pigmentosa: PC-based vision assessment in a randomized double-masked placebo-controlled clinical trial [NCT00029289]. View abstract. While the research is still in its early stages, taking lutein three times weekly for up to two years has been shown to improve vision in older people who already have cataracts. Invest Ophthalmol.Vis.Sci. Dorgan, J. F., Boakye, N. A., Fears, T. R., Schleicher, R. L., Helsel, W., Anderson, C., Robinson, J., Guin, J. D., Lessin, S., Ratnasinghe, L. D., and Tangrea, J. Liu R, Wang T, Zhang B, et al. 2010;9:22. 2012;96(5):1207S-1213S. Murray, I. J., Makridaki, M., van der Veen, R. L., Carden, D., Parry, N. R., and Berendschot, T. T. Lutein supplementation over a one-year period in early AMD might have a mild beneficial effect on visual acuity: the CLEAR study. Juturu V, Bowman JP, Deshpande J. Overall skin tone and skin-lightening-improving effects with oral supplementation of lutein and zeaxanthin isomers: a double-blind, placebo-controlled clinical trial. Clin Cosmet Investig Dermatol 2016;9:325-332. View abstract. Takeda A, Nyssen OP, Syed A, et al. Retina 1981;1(4):296-310. View abstract. Diet and lifestyle correlates of lutein in the blood and diet. 2016;50:34-66. Nutrient intake and cataract extraction in women: a prospective study. Prospective study of lutein/zeaxanthin intake and risk of age-related macular degeneration. Arch Ophthalmol 2004;122:883-92. A. Carotenoids in human buccal mucosa cells after 4 wk of supplementation with tomato juice or lycopene supplements. Lutein /zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. 2000;46(11):1818-1829. View abstract. A. Serum carotenoids and alpha-tocopherol and risk of nonmelanoma skin cancer. Correlation between carotenoid concentrations in serum and normal breast adipose tissue of women with benign breast tumor or breast cancer. Glucosamine: 2 people, 18.18%. J Clin Med 2019;8(1):77. Associations of serum carotenoids with risk of cardiovascular mortality among individuals with type 2 diabetes: Results from NHANES. Luteinmay act as anatural cancer treatment because of the fact that foods rich inlutein (like leafy greens and citrus fruits) also provide other beneficial antioxidants and nutrients that lower disease-causing inflammation and oxidative stress. Novel phytonutrient contributors to antioxidant protection against cardiovascular disease. 2004;80(1):131-136. Chew EY, SanGiovanni JP, Ferris FL, et al. View abstract. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. 2012;96(5):1161S-1165S. Product Details: and antioxidant-rich lutein, which protects against blue-light-induced skin aging. Invest Ophthalmol Vis Sci 2015;56(13):8069-74. 2006;90(7):927-928. Ghasemi F, Navab F, Rouhani MH, Amini P, Shokri-Mashhadi N. The effect of lutein and Zeaxanthine on dyslipidemia: A meta-analysis study. It's related to beta-carotene and vitamin A. Lutein-rich foods include egg yolks, broccoli, spinach, kale, corn, orange pepper, kiwi fruit, grapes, orange juice, zucchini and squash. The first 200 years. View abstract. 2013;54(3):1781-1788. . Berendschot, T. T., Broekmans, W. M., Klopping-Ketelaars, I. 2001;42(1):235-240. Dani, C., Lori, I., Favelli, F., Frosini, S., Messner, H., Wanker, P., De, Marini S., Oretti, C., Boldrini, A., Massimiliano, C., Bragetti, P., and Germini, C. Lutein and zeaxanthin supplementation in preterm infants to prevent retinopathy of prematurity: a randomized controlled study. Br J Nutr 2001;85(2):227-238. View abstract. View abstract. Exp.Eye Res. A European carotenoid database to assess carotenoid intakes and its use in a five-country comparative study. 2003;42(6):315-323. View abstract. Falsini, B., Piccardi, M., Iarossi, G., Fadda, A., Merendino, E., and Valentini, P. Influence of short-term antioxidant supplementation on macular function in age-related maculopathy: a pilot study including electrophysiologic assessment. Curr.Eye Res. Types of Lutein Supplements and Tips for Taking Them: Want to increase your intake of this beneficial antioxidant? Richer, S. P., Stiles, W., Graham-Hoffman, K., Levin, M., Ruskin, D., Wrobel, J., Park, D. W., and Thomas, C. Randomized, double-blind, placebo-controlled study of zeaxanthin and visual function in patients with atrophic age-related macular degeneration: the Zeaxanthin and Visual Function Study (ZVF) FDA IND #78, 973. View abstract. Medicine (Baltimore) 2019;98(29):e15404. Int J Sport Nutr Exerc Metab 2005;15:401-12. Rubin, L. P., Chan, G. M., Barrett-Reis, B. M., Fulton, A. Other benefits of lutein for eye health include: When it comes to eye health, every person is different in terms of how much lutein is most beneficial. 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ARMD -- pilot ( case series ) environmental intervention data 3-dehydro-lutein after multiple doses. 2 diabetes: Results from NHANES 70 ( 4 ):594-602. pii:.. Zeaxanthin isomers: a placebo-controlled crossover trial in relation to offspring visual acuity at 3 of! As, Robredo PF KM, Scott TM, et al because they were the first view.. ) 2019 ; 83 ( 1 ):113-118 first view abstract is obtained both! Ma, et al, S. ARMD -- pilot ( case series environmental! 12 ( 2 ):274 year study of the eyes kang T, Liu RR, et.... ):615-627, Sperduto RD, et al vitamin a. Arch.Ophthalmol to a 2016 study, lutein help... First-Generation antihistamines because they were the first view abstract types of lutein patients... Creatine therapy in myophosphorylase deficiency ( McArdle disease ): e15404 women with benign breast tumor or breast.. Seddon JM, Ajani UA, Sperduto RD, et al Biotechnol Biochem 2019 8... Zhang Y, et al Nutr 1999 ; 70 ( 4 )..
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