Apply using a medium quality spray using a spray pressure of 2-3 bar. Research has shown that increasing the soil water content from 17 to 26% reduced the force required for anchorage failure by 33%, and as little as 0.25 inches of water plus 11 mph winds were enough to cause lodging. corresponding official PDF file on govinfo.gov. Document Drafting Handbook Section 408(b)(2)(A)(i) of FFDCA allows EPA to establish a tolerance (the legal limit for a pesticide chemical residue in or on a food) only if EPA determines that the tolerance is safe. Section 408(b)(2)(A)(ii) of FFDCA defines safe to mean that there is a reasonable certainty that no harm will result from aggregate exposure to the pesticide chemical residue, including all anticipated dietary exposures and all other exposures for which there is reliable information. This includes exposure through drinking water and in residential settings, but does not include occupational exposure. Palisade is a giberellic acid inhibitor and works primarily by reducing plant height. Thus, the Agency has determined that Executive Order 13132, entitled Federalism (64 FR 43255, August 10, 1999) and Executive Order 13175, entitled Consultation and Coordination with Indian Tribal Governments (65 FR 67249, November 9, 2000) do not apply to this final rule. trinexapac-ethyl Chemical family: Cyclohexanecarboxylate Formulation: EC (Emulsifiable Concentrate) Product Overview Registration Application Advice Emergency Links and downloads Product overview MODDUS contains trinexapac-ethyl for use as a growth regulator in wheat, barley, oats, rye, triticale, durum wheat and ryegrass seed crops. 4-[cyclopropyl(hydroxy)methylidene]-3,5-dioxocyclohexane-1-carboxylic acid, Growth Retardant Effects Caused By Interfering With Gibberellin Biosynthesis, Plant Growth Regulators (Unclassified Plant Growth Regulators) [1]. offers a preview of documents scheduled to appear in the next day's Application of Palisade plus Tilt reduced lodging over Palisade alone at Chickasha. ).However, the seed yield responses of annual ryegrass (Lolium multiflorum Lam.) Product Name: Trinexapac-ethyl: CAS No. provide legal notice to the public or judicial notice to the courts. However, the existing legal framework provided by section 408 of FFDCA contemplates that tolerances greater than zero may be set when persons seeking such tolerances or exemptions have demonstrated that the pesticide meets the safety standard imposed by that statute. That is, a plant growth regulator will not make a lodging prone variety stand like one with excellent straw strength, rather they will make it less prone to lodging relative to the same variety non treated. Aggregate cancer risk for U.S. population. The literature also shows that reduction in lodging is relative to the straw strength of the variety. Substance Name: Trinexapac-ethyl [ISO] RN: 95266-40-3 UNII: Q89W563T9J InChIKey: RVKCCVTVZORVGD-QXMHVHEDSA-N. We conducteda separate trial evaluating Palisade in drought stress environments that was partially funded by Syngenta. 21 U.S.C. This regulation establishes tolerances for residues of trinexapac-ethyl in or on multiple commodities which are identified and discussed later in this document. 801 et seq., generally provides that before a rule may take effect, the agency promulgating the rule must submit a rule report to each House of the Congress and to the Comptroller General of the United States. 0 Chromatog on FederalRegister.gov Use the PDF linked in the document sidebar for the official electronic format. on The Agency used screening level water exposure models in the dietary exposure analysis and risk assessment for trinexapac-ethyl in drinking water. These can be useful Pursuant to the Congressional Review Act (5 U.S.C. Other names: Trinexapac-ethyl, trimethylsilyl ether Permanent link for this species. menu. 1. 1501 et seq.). on I provided 2013 results in a blog post last year, and this post provides an update including our 2014 findings. In general. However, to the best of our knowledge, TE has not been used to study the requirement of GAs in onset of germination. Remove contaminated clothes. The authority citation for part 180 continues to read as follows: Authority: EPA will submit a report containing this rule and other required information to the U.S. Senate, the U.S. House of Representatives, and the Comptroller General of the United States prior to publication of this final rule in the Federal Register. The term residential exposure is used in this document to refer to non-occupational, non-dietary exposure (e.g., for lawn and garden pest control, indoor pest control, termiticides, and flea and tick control on pets). Register, and does not replace the official print version or the official regulatory information on FederalRegister.gov with the objective of My Account; My Wishlist; My Cart; Checkout; Log In . headings within the legal text of Federal Register documents. Hangzhou,Shanghai. X. . This information is not part of the official Federal Register document. Acute risk. 801 et seq. Residential handler exposure scenarios for both dermal and inhalation are considered to be short-term only, due to the infrequent use patterns associated with homeowner products. Therefore, acute aggregate risk is equivalent to the acute dietary risk as discussed in Unit III.C.1.i. 804(2). In adult animals (rats, rabbits, mice, dogs), no systemic adverse effects are seen below the limit dose following subchronic or chronic oral exposure with the exception of dogs. Discharge into the environment must be avoided. trinexapac-ethyl is used as a foliar spray, post-emergence to control the growth on various grass species and crops. Trinexapac-ethyl is a synthetic plant growth regulator that is derived from cyclohexanecarboxylate. In addition, this final rule does not impose any enforceable duty or contain any unfunded mandate as described under Title II of the Unfunded Mandates Reform Act of 1995 (UMRA) (Pub. Therefore, based on the risk assessments and information described above, EPA concludes there is a reasonable certainty that no harm will result to the general population or to infants and children from aggregate exposure to trinexapac-ethyl residues. Mohammad Hossein Sheikh Mohammadi, et al. Do NOT wash away into sewer. For the purposes of this tolerance action, therefore, EPA has assumed that trinexapac-ethyl does not have a common mechanism of toxicity with other substances. No. offers a preview of documents scheduled to appear in the next day's Molecular Formula CHO. If these high yield potential acres are being sprayed with a growth regulator at GS 7, the addition of a foliar fungicide might be prudent if it can be included at a relatively low cost. Roanoke, VA 24016. Aggregate Risk Assessment and Determination of Safety, B. Toxicological Points of Departure/Levels of Concern, D. Safety Factor for Infants and Children, E. Aggregate Risks and Determination of Safety, D. Revisions to Petitioned-For Tolerances, VI. Trinexapac-ethyl 11.3% Sl 25 Ec 95% Tc Trinexapac-ethyl Plant Growth Regulator , Find Complete Details about Trinexapac-ethyl 11.3% Sl 25 Ec 95% Tc Trinexapac-ethyl Plant Growth Regulator,Trinexapac-ethyl 11.3% Sl,Trinexapac-ethyl 25 Ec,Trinexapac-ethyl Plant Growth Regulator from Plant Growth Regulator Supplier or Manufacturer-Shanghai Sinogreatland Industrial Co., Ltd. Based on the Pesticide Root Zone Model/Exposure Analysis Modeling System (PRZM/EXAMS) and Screening Concentration in Ground Water (SCI-GROW) models, the estimated drinking water concentrations (EDWCs) of trinexapac-ethyl for acute exposures are estimated to be 12.61 parts per billion (ppb) for surface water and 0.009 ppb for ground water. The toxicology database for trinexapac-ethyl is largely complete, with the exception of a subchronic neurotoxicity study, which is a new data requirement under 40 CFR part 158 for registration of a pesticide (food and non-food uses OPPTS 870.6200b). documents in the last year, 287 Short-, intermediate-, and chronic-term risks are evaluated by comparing the estimated aggregate food, water, and residential exposure to the appropriate PODs to ensure that an adequate MOE exists. 02/28/2023, 239 In the event of a Toxic or Transport Emergency in the UK please telephone 01484538444 at any time. Avoid contact with skin and eyes. Since tolerances and exemptions that are established on the basis of a petition under FFDCA section 408(d), such as the tolerance in this final rule, do not require the issuance of a proposed rule, the requirements of the Regulatory Flexibility Act (RFA) (5 U.S.C. 1. on Document Drafting Handbook document.write(" Prin<\/span>t<\/a> \"Print\"<\/a>\u00A0|") Refer for medical attention . Bell. Trinexapac-ethyl. Incidental oral (short and intermediate-term), No appropriate endpoint for the incidental oral scenario for children, Dermal & Inhalation (short- and intermediate-term-adults only), Dermal (or oral) study NOAEL = 60 mg/kg/day (dermal absorption rate = 77.5%. These effects in the dog study were observed only at high doses (>357 mg/kg/day) and with chronic exposure, and no associated neurological signs or other neuropathology were observed. Relevant information about this document from Regulations.gov provides additional context. C. How can I file an objection or hearing request? EPA considers the international maximum residue limits (MRLs) established by the Codex Alimentarius Commission (Codex), as required by FFDCA section 408(b)(4). Acting as a growth inhibitor, this chemical can be used to prevent lodging in crops. ii. This final rule does not contain any information collections subject to OMB approval under the Paperwork Reduction Act (PRA), 44 U.S.C. Germination studies were conducted using seeds of artichoke thistle and common teasel under a range of TE . (a) General. Based on these risk assessments, EPA concludes that there is a reasonable certainty that no harm will result to the general population, or to infants and children from aggregate exposure to trinexapac-ethyl residues. Rolston, C.J. Export Percentage. Our results are consistent with other wheat plant growth regulator research, which has reported similar variation in response among sites and years. The Public Inspection page may also This final rule directly regulates growers, food processors, food handlers, and food retailers, not States or tribes, nor does this action alter the relationships or distribution of power and responsibilities established by Congress in the preemption provisions of section 408(n)(4) of FFDCA. documents in the last year, 24 Our results are consistent with other wheat plant growth regulator research, which has reported similar variation in response among sites and years. Trinexapac-ethyl mainly used on graminoid & fruit trees.Trinexapac-ethyl is approved for use on cereal crops such as barley, durum wheat, oats, rye, triticale and wheat as well as grassland, amenity turf and managed turf. About the Federal Register Residues were extracted from wheat with acetonitrile in aqueous phosphate buffer (pH 7) overnight. EPA may establish a tolerance that is different from a Codex MRL; however, FFDCA section 408(b)(4) requires that EPA explain the reasons for departing from the Codex level. Remove contact lenses, if present, after the first 5 minutes, then Seed weight was generally inversely related to yield; trinexapac-ethyl treatments that produced the highest yield also had the lowest seed weight. Design Philosophy From Female Golf Course Architects. Due to public health concerns related to COVID-19, the EPA Docket Center and Public Reading Room are closed for the time being, although EPA staff are continuing to provide remote assistance. Classification Codes. Compliance with the tolerance levels is to be determined by measuring both trinexapac-ethyl, ethyl 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate and the associated metabolite trinexpac, 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylic acid, calculated as the stoichiometric equivalent of trinexapac-ethyl. 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