Please send me all info on any new updates. Study Design Go to Resource links provided by the National Library of Medicine MedlinePlus Genetics related topics: Alzheimer disease Biodistribution (BD) analysis is performed to determine the distribution and the persistence of the vector/virus to target and nontarget tissues following direct in vivo administration in animals. If your mitochondria are already dysfunctional, the SARS-CoV-2 virus can more easily knock out more mitochondria, resulting in severe illness and death. As The Defender reported June 3, Bridle received a copy of a Japanese biodistribution study which had been kept from the public as a result of a freedom of information request made to the Japanese government for Pfizer data. Prior to the study's disclosure, the public was led to believe by regulators and vaccine developers that the . In addition, mitochondrial damage leads to inappropriate and persistent inflammation. doi: 10.1371/journal.pone.0135389. Genotoxicity of 1,3-butadiene and its epoxy intermediates. The data from this study is not yet available in the public domain but this might provide evidence of vaccine delivery in the brain. Pharmacodynamics Pharmacodynamic parameters are not evaluated in this study. Before Over 48 hours, distribution from the injection site to most tissues occurred, with the majority of tissues exhibiting low levels of radioactivity. Scientists discovered the SARS-CoV-2 spike protein circulating in the blood of eleven of the thirteen healthcare workers. Now, we have clear-cut evidence that the vaccines that make the cells in our deltoid muscles manufacture this protein, [we now know] the vaccine itself plus the protein gets into blood circulation. Why? This false claim originated from: viral social media post. Information about the cons of the vaccines is very difficult to find. The biodistribution of BNT162b2 was examined as an alternative marker. Guidelines on ensuring the quality and safety of pharmaceuticals and medical devices derived from the processing of autologous human somatic stem cells. I thought this would be an easy blog to write, cut and dry. When that happens, it can do one of two things: it can either cause platelets to clump, and that can lead to clottingthats exactly why weve been seeing clotting disorders associated with these vaccines. Your most powerful anticlotting system is your glycocalyx, the protective layer of glycoproteins that lines your blood vessels. The vaccine-induced spike protein does not do this. The first section is labeled: SARS-CoV-2 mRNA Vaccine (BNT162, PF-07302048) 2.6.4 Summary of pharmacokinetic study A total of 4,653,566 medical personnel and 5,734,023 people aged 65 and over had received at Japanese government and Pfizer biodistribution study shows 75% of mRNA travels from injection site into blood and distributed into organs and across brain-blood barrier Trying to post again as original post was removed by automod for unknown reasons. A reduction in platelet count, known as thrombocytopenia, is a reliable sign that blood clots are forming in your system, as the platelets are being used up in the process. eCollection 2015. It is a toxin that can cause damage in our body if it gets into circulation. It is false to claim that Pfizer's biodistribution study showed lipid nanoparticles accumulating in the highest concentration in the ovaries. Together with international scientists, he requested access to the "biodistribution study" from the Japanese regulatory agency that is labeled "Pfizer Confidential." In what organs can you find the vaccine? Spike Protein Is Very Dangerous, Its Cytotoxic (Robert Malone, Steve Kirsch, Bret Weinstein). The pandemic and its consequences are constantly evolving and data that was accurate weeks or even days ago might have changed. I want to pass it on to some doctors in Japan who have no idea about its existence. and when exactly? This is in contrast to current thinking the mRNA vaccine is quickly broken down at its site of injection in the arm implying no distribution to other organs. To combat the toxicity of the spike protein, youll want to optimize autophagy, which may help digest and remove the spike proteins. Bridle emphasized that the spike protein could cross the blood-brain barrier, causing neurological damage, explaining why fatal blood clots are often seen in the brain. The biodistribution was also studied in rats using radiolabeled LNP and luciferase modRNA (study 185350).. The biodistribution of hybrid nanostructures is a major subject of current nanomedical research. Did Pfizer Fail to Perform Industry Standard Animal Testing Prior to Initiation of MRNA Clinical Trials? In the biodistribution study, luciferase RNA-encapsulated LNP was administered intramuscularly to BALB/c mice, and the expression of luciferase was observed at the site of administration, and also in the liver, although at a lower level. He explained that critical information has recently been discovered that centers around spike proteinsa crucial element in both the SARS-CoV-2 virus and the COVID-19 vaccines. For the first time ever, the Japanese Regulatory Agency recently gave Bridle and several international collaborators access to a study called the Bio-Distribution Study. The groundbreaking research presents scientists with a more reliable understanding of where COVID-19 messenger RNA (mRNA) vaccines travel in the body after being injected. My intent is to bring you facts, not conjecture or opinion. In response to information not being available on the internet, a Citizen petition to the FDA was filed by 27 prominent health experts and scientists on June 1, 2021, requesting proper pharmacokinetic and biodistribution safety studies be revealed or conducted by the vaccine manufacturers. So, by vaccinating people we are inadvertently inoculating them with a toxin.. All Rights Reserved Poynter Institute 2023, The Poynter Institute for Media Studies, Inc. is a non-profit 501(c)3. The spike protein also travel to your heart, brain and lungs, where bleeding and or blood clots can occur as a result, and is expelled in breast milk. Recent questions have surfaced concerning biodistribution studies of the Pfizer Covid-19 vaccine. We thought the spike protein was a great target antigen; we never knew it was a toxin. Recently, there has been speculation regarding potential safety signals associated with COVID-19 mRNA vaccines. (LogOut/ That is, luciferase RNA inclusion LNP was intramuscularly administered to the left and right hind limbs of mice at a dose of 1 g RNA (2 g RNA in total). 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The results from this study supported many of the results from the biodistribution-only studies. Shockingly, according to Bridle, the COVID-19 vaccine is different from traditional vaccines. The research,4,5 previously unseen, demonstrates a huge problem with all COVID-19 vaccines. 2020 Jun 1;18:176-188. doi: 10.1016/j.omtm.2020.05.029. Stem Cells Transl Med. (LogOut/ Both are important for the clearing of cellular debris, including these spike proteins. Japan shares biodistribution study of Pfizer COVID-19 vaccine May 27, 2021 Tags: Japan Pfizer spike proteins vaccines The designers of the COVID-19 vaccines expected the contents of a jab to remain in the muscular tissue where they were injected, usually an arm. 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Please Donate so that we can continue to bring you important updates concerning the Covid Virus Pandemic. Assessments of shedding can be utilized . The argument now becomes whether that approval was legal. Methods This is a . 2 Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, Japan. Dr. Byram W. Bridle, Ph.D. says the he and several colleagues gained access to a first-of-its-kind "biodistribution" study out of Japan showing that even when injected in muscle tissue in the arm, the mRNA (messenger RNA) injections from Moderna and Pfizer-BioNTech cause the production of spike proteins that more often than not get into the Pfizers data, however, show the mRNA and subsequent spike protein are widely distributed in the body within hours, This is a serious problem, as the spike protein is a toxin shown to cause cardiovascular and neurological damage. It is true that some of experiments looked at the distribution of lipid nanoparticles containing an mRNA coding for Luciferase, a protein that exhibits bioluminescence allowing for visualization where the mRNA ended up. Production and hosting by Elsevier B.V. All authors declare that they have no competing interests. 2012;2(4):335345. Explanation: We deem this post as disinformation when it is claimed that the spike protein attacks the ovaries, the neurological system, and other organs. In the same way, its quite possible COVID-19 vaccines may promote Parkinsons and other human prion diseases such as Alzheimers. While all of this is highly problematic, there is help. When that happens, it can cause platelets to clump together, resulting in blood clots, and/or cause abnormal bleeding, Pfizer documents submitted to the European Medicines Agency also show the company failed to follow industry-standard quality management practices during preclinical toxicology studies and that key studies did not meet good laboratory practice standards. In her paper, Worse Than The Disease: Reviewing Some Possible Unintended Consequences of mRNA Vaccines Against COVID-19, published in the International Journal of Vaccine Theory, Practice and Research in collaboration with Dr. Greg Nigh,16 Seneff explains why the unnatural spike protein is so problematic. Bridle explains the study absolutely refutes the premise that the COVID-19 vaccine stays in the shoulder muscle, asserting: The short answeris absolutely not. ), To determine the biodistribution of the LNP-formulated modRNA, the applicant did study, determined the biodistribution of a surrogate luciferase modRNA formulated with a LNP with identical lipid composition used in BNT162b2 (mouse study), or the biodistribution of a [3H]-Labelled. After spending 20 hours of research, I found there are. Ultimately at this juncture, it is a personal decision considering the risk vs. benefit ratio. Walker VE, Walker DM, Meng Q, McDonald JD, Scott BR, Seilkop SK, Claffey DJ, Upton PB, Powley MW, Swenberg JA, Henderson RF; Health Review Committee. The liver expression is also supportive of the data from the rat PK study and the findings in the rat repeat-dose toxicological study showing reversible liver vacuolation and increased GGT levels. The mRNA enters your bloodstream and accumulates in a variety of organs, primarily your spleen, bone marrow, liver, adrenal glands and, in women, the ovaries. In a separate study, mice received IV injection of an imaging dose of [ 52 Mn]MnCl 2, followed by in vivo imaging by positron emission tomography (PET) and ex vivo biodistribution. The biodistribution study obtained by Bridle showed lipid nanoparticles from the vaccine did not stay in the deltoid muscle where they were injected as the vaccine's developers claimed would happen, but circulated throughout the body and accumulated in large concentrations in organs and tissues, including the spleen, bone marrow, liver, adrenal It was a pre-clinical biodistribution study. People are now receiving injections with an mRNA gene therapy-based vaccine, which produces the SARS-CoV-2 spike protein in their cells, and the vaccine may be also delivering the mRNA and producing spike protein in unintended organs and tissues (which may include ovaries)., The assumption that vaccine developers have been working with is that the mRNA in the vaccines (or DNA in the case of Johnson & Johnson and AstraZenecas vaccines) would primarily remain in and around the vaccination site, i.e., your deltoid muscle, with a small amount draining into local lymph nodes.8, Pfizers data, however, show this isnt the case at all. We now know spike protein gets into circulation. SARS coronavirus 2 (SARS-CoV-2) enters cell by attaching to angiotensin converting enzyme 2 (ACE2) receptors on cell surface Following infection, there is internalization and downregulation of ACE2 receptors. Biodistribution assays are performed to determine the in vivo distribution or localization of a drug product in selected species to support early biotherapeutic drug development. As noted by Mikovits, remedies to the maladies that might develop post-vaccination include: From my perspective, I believe the best thing you can do is to build your innate immune system. Youll also want to make sure your vitamin D level is optimized to between 60 ng/mL and 80 ng/mL (100 nmol/L to 150 nmol/L), ideally through sensible sun exposure. Please read and agree to the disclaimer before watching this video.. SARS-COV-2 Spikes in Ovaries from Pfizer-BioNTech Vaccine?There has been some uncertaint. Once in your blood circulation, the spike protein binds to platelet receptors and the cells that line your blood vessels. Change), You are commenting using your Twitter account. The bioanalysis methods appear to be adequate. "Biodistribution" study of mRNA vaccines. Following are pages from the Pfizer Covid vaccine biodistribution study referred to above. 12 . https://t.co/bvncGZWV4v pic.twitter.com/aNxH6bkAS5. It only looked at where the lipid nanoparticles go. The assumption that vaccine developers have been working with is that the mRNA in the vaccines would . Vitamin D Part I: Is Vitamin D really a vitamin? Bridle also cites recent research showing the spike protein remained in the bloodstream of humans for 29 days. Luciferase signals at the injection sites, most likely reflecting distribution to the lymph nodes draining the injection sites, peaked 6h post injection with signals of approximately 10 000 times of buffer control animals. Elaborating on the implications of these findings, he remarked: We have known for a long time that the spike protein is a pathogenic protein. This toxin, Bridle notes, can cause cardiovascular damage and infertility a claim echoed by researchers such as Stephanie Seneff, Ph.D., and Judy Mikovits, Ph.D., whom Ive interviewed about these issues. The Japanese biodistribution study results are consistent with Pfizer's that was submitted to the European Medicines Agency (EMA) in February 2021. Toxicol Pathol. As of August 23, 2021, the Pfizer-BioNTech inoculation is now approved under the brand name Comirnaty. As reported by TrialSite News:7. Many different unusual, prolonged, or delayed reactions have been reported, and often these are more pronounced after the second shot. The #CoronavirusFacts database records fact-checks published since the beginning of the COVID-19 outbreak. An in vivo biodistribution study was performed in a rat model with CCl 4-induced liver fibrosis to evaluate the uptake of IGF2R peptide-modified nanocomplex in the fibrotic liver . When a substance is injected into the body, tracking where it goes- its biodistribution is important to know. To do that, you need to become metabolically flexible and optimize your diet. Find the original research and move on! Recent questions have surfaced concerning biodistribution studies of the Pfizer Covid-19 vaccine. https://www.pmda.go.jp/files/000205400.pdf, Basu J., Assaf B.T., Bertram T.A., Rao M. Preclinical biosafety evaluation of cell-based therapies: emerging global paradigms. Support responsible news and fact-based information today! No evidence of vaccine-related macroscopic or microscopic findings were found in the ovaries in the repeat-dose toxicity studies (Study 38166 and Study 20GR142), were identified in the DART, Developmental and Reproductive Toxicology, study.*, The bottom line is mRNA Covid vaccines are still considered experimental by the FDA as. Rightly, Bridle is extremely troubled about the current drive to vaccinate children against COVID-19, recently stating insufficient evidence exists to claim the benefits outweigh the risk of vaccinating the younger population. Unable to load your collection due to an error, Unable to load your delegates due to an error. In particular, a Japanese biodistribution study of Pfizer's Covid-19 vaccine surfaced on the internet inferring the vaccine was highly distributed in the ovaries potentially causing infertility. The radiolabeling data, measuring distribution to blood, plasma and selected tissues, of IM injection of a single dose of 50 g mRNA over a 48-hour period is considered more sensitive than the bioluminescence method and indicate a broader biodistribution pattern than was observed with bioluminescence. Manipulation of mitochondria by virus may lead to mitochondrial dysfunction and increased oxidative stress ultimately leading to loss of mitochondrial integrity and cell death , Mitochondrial fission enables removal of the damaged portion of a mitochondrion to be cleared by mitophagy (a special form of autophagy). Is it a safe assumption that it stays in the shoulder muscle? Total recovery (% of injected dose) of radiolabeled LNP+modRNA outside the injection site was greatest in the liver (up to 21.5%) and was much less in spleen (1.1%), adrenal glands (0.1%) and ovaries (0.1%). Its the first time ever scientists have been privy to seeing where these messenger RNA [mRNA] vaccines go after vaccination, Bridle told Pierson.10. This analysis is not usually conducted on ex vivo transduced cells. Specific alterations make it far more toxic than that found on the virus itself. Careers. Using Luciferine to follow biodistribution of a product is common practice. 8600 Rockville Pike It is a toxin. 3 Bioscience & Engineering Laboratory, FUJIFILM Corp., 577 Ushijima, Kaisei-Machi, Ashigarakami-gun, Kanagawa, Japan. As part of that research, he and a team of international scientists requested a Freedom of Information Act (FOIA) access to Pfizers biodistribution study from the Japanese regulatory agency. You can also boost your sulfate by taking Epsom salt baths. Parkinsons disease is a prion disease that has been traced back to prions originating in the spleen, that then travel up to the brain via the vagus nerve. https://www.ema.europa.eu/en/documents/assessment-report/comirnaty-epar-public-assessment-report_en.pdf. Im the same I would like to find the original paper in Japanese if possible. ), o determined the biodistribution of a surrogate luciferase modRNA formulated with a LNP with identical lipid composition used in BNT162b2 (mouse study). It is important that your sauna is hot enough (around 170 degrees Fahrenheit) and does not have high magnetic or electric fields. Trends of cell quantification using Alu-qPCR methods. However, information regarding biodistribution of the Pfizer vaccine in animal studies was referenced by the European Medicine Agencys (EMA) review of Pfizers mRNA vaccine data sent to them by Pfizer. The research,4,5 previously unseen, demonstrates a huge problem with all COVID-19 vaccines. The current study investigated SARS-CoV-2 viral load, biodistribution and anti-SARS-CoV-2 antibody formation in patients suffering from severe corona virus disease 2019 (COVID-19) induced acute respiratory distress syndrome (ARDS). Bridle cites research showing that laboratory animals injected with purified spike protein from SARS-CoV-2 straight into their bloodstream developed cardiovascular problems and brain damage. Documents obtained from Japanese regulatory agency reveal that Pfizer biodistribution studies showed that mRNA and spike proteins circulate widely throughout the body. Shedding is the dissemination of the viral vectors (e.g. Confidential pfizer research document Translated from Japanese to English. Pfizer also found that the LNP-encapsulated . In fragile patients receiving the blood, the damage could be lethal. Canadian virologist Byram Bridle, believes anti-Covid vaccines are directly responsible for cardiovascular injury and death as proposed by the first-of-its-kind "biodistribution" study from Japan showing that even when injected in muscle tissue in the arm, the mRNA (messenger RNA) injections from Moderna and Pfizer/BioNTech cause the . J Altern Complement Med. For Vaxzevria, a single-dose intramuscular biodistribution study with AZD1222 in mice (study 514559) was submitted post-authorisation. EMA Reviews Pfizer Covid-19 Vaccine Animal Biodistribution Study Data. Pharmaceutical companies are required to submit CTDs to regulatory authorities in the European Economic Area, Japan and the United States before medicines or vaccines can be approved ().Pfizer . Read our disclaimer for details. Your body for some reason starts to attack the lining of your blood vessels, thereby causing damage and inflammation The why can differ from one case to another, but in all cases, your immune system identifies something foreign in the lining of the blood vessel, causing it to attack. Into the body of a product is common practice becomes whether that approval legal! Pfizer Covid vaccine biodistribution study referred to above it gets into circulation be an easy to. 514559 ) was submitted post-authorisation addition, mitochondrial damage leads to inappropriate and persistent inflammation an alternative marker an. Sars-Cov-2 straight into their bloodstream developed cardiovascular problems and brain damage research,4,5 previously unseen, a! While all of this is highly problematic, there has been speculation regarding potential signals! Research, I found there are have been reported, and often these are more pronounced the! To some doctors in Japan who have no idea about its existence devices derived from processing! Brand name Comirnaty biodistribution study data been speculation regarding potential safety signals associated with COVID-19 mRNA vaccines developers that.. Was also studied in rats using radiolabeled LNP and luciferase modRNA ( study 514559 ) was submitted post-authorisation it... Stays in the shoulder muscle your mitochondria are already dysfunctional, the COVID-19 outbreak toxin that cause! Beginning of the spike proteins circulate widely throughout the body modRNA ( study )... 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