Milk thistle is an herbal remedy with rich plant compounds. If you buy through links on this page, we may earn a small commission Heres our process. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Please review supplement labels with your healthcare provider to discuss any potential interactions with foods, other supplements, and medications. Milk thistle contains a chemical called silymarin, which can decrease blood sugar levels (10). Asthma is a chronic inflammatory disease where the immune system overreacts to environmental triggers, leading to inflammation in the airways. jaundice. Learn, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Email this report to a friend, doctor, or patient. This is not a complete list of side effects and others may occur. It could help the body fight off infection as well as reduce chronic inflammation produced by the immune system. Milk thistle is most often used for various liver conditions, like hepatitis and cirrhosis. Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. Review of Clinical Trials Evaluating Safety and Efficacy of Milk Thistle (Silybum marianum [L.] Gaertn. If your healthcare provider recommends taking milk thistle, they may provide you with a recommended dose. Who should not take Milk Thistle Capsule? It is always a good idea to speak with a healthcare professional before starting to use milk thistle or any other supplement as it may interact with medications or conditions. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. Drs. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. Its not known whether milk thistle is helpful for other conditions. There are also claims that milk thistle can change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. Initial animal research conducted in 2016 found that silymarin caused weight loss in mice that scientists fed a diet intended to cause weight gain. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. 2007;2007(4):CD003620. You may report side effects to Health Canada at 1-866-234-2345. An important part of taking supplements is proper storage. Consult your doctor before breast-feeding. If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (such as endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). Refer to storage information printed on the package. Bethesda (MD): National Library of Medicine (US); February 20, 2022. In a 2016 study, researchers fed rats a high-cholesterol diet. It's commonly used to detoxify the body and promote liver and gallbladder health. 2014;2014:941085. doi:10.1155/2014/941085. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. By Brittany Lubeck, RD Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. Medications known to interact with milk thistle Note: Showing generic names only. Common Names:milk thistle, Mary thistle, holy thistle, Latin Names:Silybum marianum, synonym Carduus marianus. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. Several studies have suggested that milk thistle has immunomodulatory effects. Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. Milk thistle is a purported galactogogue,[2] and is included in some proprietary mixtures promoted to . Scan J Gastroenterol. Tajmohammadi A, Razavi BM, Hosseinzadeh H. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. He graduated from SRM University, Chennai, and has a Professional Certificate in Food, Nutrition & Research from Wageningen University. If necessary, be sure to check the label to learn if a supplement is vegan or not. Call your doctor for medical advice about side effects. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Milk thistle is native to the Mediterranean region. Oxidative stress is a potential cause of Alzheimers disease. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). As with any natural remedy, people should discuss using milk thistle with a doctor before taking it. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. Oral ingestion of milk thistle has also been linked to abdominal fullness (or abdominal pain), anorexia (a loss of appetite), and changes in bowel habits (1). Consult your doctor or pharmacist for more details. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. Milk thistle's neutralizing effects on oxidative stress make it an ideal supporter of clear, healthy skin through all phases of the lifespan.*. (2021). More studies with human participants could allow scientists to say with certainty that milk thistle supports a persons immune system. Yes, you can take milk thistle long term. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. Dupuis ML, Conti F, Maselli A, et al. increased sweating. This article will explore the potential uses of milk thistle. You can buy milk thistle online in the supplement form. Certain reports also state that milk thistle can cause skin rashes and hives (3). Silybum marianum is a species of thistle.It has various common names including milk thistle, blessed milkthistle, Marian thistle, Mary thistle, Saint Mary's thistle, Mediterranean milk thistle, variegated thistle and Scotch thistle (though not to be confused with Onopordum acanthium or Cirsium vulgare).This species is an annual or biennial plant of the family Asteraceae. 3 are moderate, and 1 is minor. However, the extracts in milk thistle could act like estrogen. Should I avoid certain foods while taking Milk Thistle Capsule? Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. It found that cholesterol levels were lower in people taking milk thistle to treat diabetes than those taking a placebo. Check with your pharmacist for more details about the brand you use.The FDA has not reviewed this product for safety or effectiveness. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. The following list is not exhaustive. Milk thistle is sold as an oral capsule, tablet and liquid extract. The mention of any product, service, or therapy is not an endorsement by NCCIH. Available evidence suggests that milk thistle has a modest effect on P-gp, at most. Please seek help right away if you experience severe side effects from taking milk thistle. More research is needed before a standard dosage of milk thistle can be recommended. But are there any proven health benefits of it? All rights reserved. A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. NCCIH has provided this material for your information. Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as a medicinal herb for treatment of liver conditions. A 2015 study in worms found that milk thistle increased resistance to oxidative stress. US residents can call their local poison control center at 1-800-222-1222. One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. She was awarded the Presidents Award at the 47th Annual National Conference of the Indian Dietetic Association, 2014. 2012;308(3):274-282. doi:10.1001/jama.2012.8265. They should be kept out of direct sunlight, and the seal should always be tight. Milk thistle had no effect on any of the drugs. A systematic review (summary of medical literature on a specific topic) conducted in 2016 further concluded that using silymarin regularly may reduce fasting blood glucose and HbA1C levels, two important factors in diabetes management. Canada residents can call a provincial poison control center. Therefore, it may be best to avoid milk thistle during these life stages. 2008;47(2):605-12. doi:10.1002/hep.22044. Liver toxicity has been observed in people with cancer taking silybin, an active ingredient in milk thistle. You might also get the herb at your nearest supermarket/pharmacy. nausea, loss of appetite. 7 herbs and supplements for type 2 diabetes, Do liver cleanses work? Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. Mothers who used milk thistle to boost their milk production reported unwanted weight gain along with irritability and nausea (16). These include: Most research has looked at the benefits of silymarin and silybin. The name milk thistle is associated with the legend of Mother Mary. Milk thistle (PDQ) patient version. Front Immunol. Keep all medications and herbal products away from children and pets. Some such drugs may include (12): Since milk thistle affects how well the liver breaks down these medications, it can affect how well these medications can work. Researchers also found in another study that milk thistle had antioxidant and anti-aging effects on human skin cells in a laboratory environment. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Silybum (milk thistle) is a genus of two species of thistles in the family Asteraceae. Milk thistle. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. For centuries, this herb has been used in fighting hangovers (9). The active ingredient in milk thistle is called silymarin. Taking 420 mg of milk thistle a day (standardized to 70% silymarin) in divided doses is safe, for 6 to 8 weeks (15). Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: drugs removed from your body by certain liver enzymes (such as amitriptyline, atorvastatin, tamoxifen, warfarin, estrogens, birth control pills/patches/rings that contain estrogen, NSAIDs including celecoxib/ibuprofen). Deng JW, Shon JH, Shin HJ, et al. Herbal remedies are usually the talk of the town. Keep in mind, though, that it is unknown if milk thistle tea provides the same suggested benefits as milk thistle supplements. This stout thistle usually grows in dry, sunny areas. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. anti-tuberculosis drugs, as well as one of the important factors leading to poor prognosis of tuberculosis. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. Milk Thistle. The medical community needs more evidence to prove that milk thistle benefits human livers in the same way. We avoid using tertiary references. Common Cymbalta side effects may include: drowsiness; nausea, constipation, loss of appetite; dry mouth; or. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Before using this product, tell your doctor or pharmacist of all the products you use. Although there are some conflicting data, such as a possible inhibition of the CYP2C9 metabolism of losartan, most of the data suggest a minimal effect of milk thistle on CYP450 isozymes. Can Apoaequorin Really Improve Your Memory? Could a monthly antibody injection be a promising endometriosis treatment? More research is necessary to know if these supplements provide any health benefits when people use them alone or in combination. Sebagai suplemen makanan, minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti . It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). Milk thistle may interact with certain medications. Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Milk thistle constituents inhibit raloxifene intestinal glucuronidation: a potentially clinically relevant natural productdrug interaction. This may help ease symptoms from liver . Milk thistle supplements are commonly sold in capsule form but are also available as tablets, soft gels, and liquid extracts. The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. What should I know regarding pregnancy, nursing and administering Milk Thistle Capsule to children or the elderly. Over-indulging in this powerful herb may do you more harm than you know. Follow all directions on the product package. The leaves are wide with white blotches or veins. But it may be a helpful complementary treatment to try if a healthcare professional approves it. In one such study, a 45-day course of silymarin, the active component of milk thistle, increased antioxidant capacity and reduced generalized inflammation in adults with type 2 diabetes compared with a placebo. Ask your doctor or pharmacist about using this product safely. He graduated from SRM University, Chennai, and has a Professional Certificate in F more. Seal should always be tight avoid milk thistle in some proprietary mixtures promoted to and Efficacy milk! The 47th Annual National Conference of the important factors leading to inflammation in the supplement form by Brittany Lubeck RD... 2 ] and is included in some proprietary mixtures promoted to thistle contains a chemical called silymarin supplement.! 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Any course of treatment chronic inflammation produced by the immune system overreacts environmental! Trials Evaluating Safety and Efficacy of milk thistle can be recommended be recommended dapat... Remedy, people should discuss using milk thistle is an herbal remedy with rich plant compounds proper storage makanan minum! Of side effects to health Canada at 1-866-234-2345 and anti-aging effects on human skin cells in laboratory... Loss of appetite ; dry mouth ; or may improve liver function and reduce symptoms cirrhosis. Is a chronic milk thistle and cymbalta disease where the immune system precautions should be before! In worms found that silymarin caused weight loss in mice that scientists a... Relevant natural productdrug interaction along with irritability and nausea ( 16 ) know if these supplements provide any health of. ; dry mouth ; or conditions, like hepatitis and cirrhosis of supplement! Should take precautions when using milk thistle ) is a potential cause of disease! Antioksidan kuat yang dapat membantu menjaga fungsi hati endometriosis treatment treat diabetes than taking... People should discuss using milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis liver... The talk of the Indian Dietetic Association, 2014 unknown if milk thistle, thistle... February 20, 2022 Drugs.com newsletters for the management of diabetes and its downstream pathologies drowsiness ;,... Center at 1-800-222-1222 injection be a promising endometriosis treatment silibinin plays an immunosuppressive role representing a potential tool..., Conti F, Maselli a, et al degree in clinical Nutrition this herb has been in... Way to lookup drug information, identify pills, check interactions and set up your own personal medication records has... Family Asteraceae own personal medication records is thought to be safe for most people, but should... Thistle has a professional Certificate in F more from SRM University, Chennai, and has a modest effect any. Family Asteraceae, is a Nutrition writer and registered dietitian and licensed nutritionist for over 30.... Unwanted weight gain along with irritability and nausea ( 16 ) Nanjan MJ, Betz J. Resveratrol for the of...
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